PRINCIPAL INVESTIGATOR
![trippier_paul](https://www.trippierlab.com/wp-content/uploads/2024/02/trippier_paul.jpg)
Paul Trippier, PhD
Paul received an M.Chem. in Chemistry, Drug Design, and Toxicology with first class honors from the University of Hull in the United Kingdom (UK). He completed his graduate studies in Synthetic Organic Chemistry at Oxford University, UK with Prof. Mark Moloney. He conducted postdoctoral research with Prof. Chris McGuigan at Cardiff University, UK and then with Prof. Rick Silverman at Northwestern University, Evanston, IL.
Dr. Trippier’s research is focused on small molecule drug discovery for cancer and neurodegenerative diseases. His lab employs synthetic medicinal chemistry, chemical biology and molecular pharmacology techniques to design, optimize and employ biologically active compounds as chemical probes to interrogate novel pathways relevant to human disease and as lead compounds for novel drug discovery.
Discoveries in the Trippier lab have led to the identification of the most potent and selective Aldo-keto reductase 1C3 (AKR1C3) inhibitor which shows significant effect to counter drug resistance in prostate cancer and leukemia; best-in-class synthetic succinate dehydrogenase inhibitors with significant anticancer activity; novel multi-targeted agents for neurodegenerative disease therapy; and first-in-class activators of neurolysin for stroke therapy development.
POST DOCS
![Sravan2](https://www.trippierlab.com/wp-content/uploads/2024/04/Sravan2-rotated.jpeg)
Sravan Jonnalagadda, Ph.D.
University of Minnesota
Joined August 2019
![George Hao](https://www.trippierlab.com/wp-content/uploads/2024/04/George-Hao-scaled.jpeg)
Xiaoyu ‘George’ Hao, Ph.D.
Sichuan University, P. R. China
Joined January 2022
![Aarfa Queen](https://www.trippierlab.com/wp-content/uploads/2024/04/Aarfa-Queen-scaled.jpeg)
Aarfa Queen, Ph.D.
Jamia Millia Islamia University, India
Joined January 2022
![Ramu](https://www.trippierlab.com/wp-content/uploads/2024/04/Ramu-scaled.jpg)
Ramu Venkatesan, Ph.D.
Gachon University, Incheon, South Korea
Joined October 2022
GRADUATE STUDENTS
![Louise](https://www.trippierlab.com/wp-content/uploads/2024/04/Louise-scaled.jpeg)
Louise Dow (G3)
M.Chem. Heriot-Watt University, UK.
Joined January 2021
![Princess](https://www.trippierlab.com/wp-content/uploads/2024/04/Princess-scaled.jpeg)
Princess Simeon (G3)
BS. Central State University, OH.
Joined May 2022
![Hamdan](https://www.trippierlab.com/wp-content/uploads/2024/04/Hamdan-scaled.jpeg)
Hamdan Alrefaei (G2)
MS. University of Mississippi, MS.
Joined January 2022
![Megan](https://www.trippierlab.com/wp-content/uploads/2024/04/Megan-scaled.jpg)
Megan Paustian (G2)
BS. University of Nebraska at Omaha, NE.
Joined August 2022
![Alfie Case](https://www.trippierlab.com/wp-content/uploads/2024/04/Alfie-Case-scaled.jpg)
Alfie Case (G2)
M. Chem. University of Southampton, UK.
Joined August 2022
![Jerad](https://www.trippierlab.com/wp-content/uploads/2024/04/Jerad-rotated.jpeg)
Jared Bogenhagen (MS1)
B.S. University of Nebraska at Omaha, NE
Joined January 2024
UNDERGRADS & PHARMACY STUDENTS
![person-placeholder-darker](https://www.trippierlab.com/wp-content/uploads/2024/02/person-placeholder-darker.png)
Melanie Smith